{"id":6898,"date":"2024-01-15T10:00:35","date_gmt":"2024-01-15T08:00:35","guid":{"rendered":"https:\/\/eu.bd.com\/iv-news\/?p=6898"},"modified":"2024-02-21T09:58:36","modified_gmt":"2024-02-21T08:58:36","slug":"antibiotics-shortages-in-europe-what-you-need-to-know","status":"publish","type":"post","link":"https:\/\/eu.bd.com\/iv-news\/news-innovation\/antibiotics-shortages-in-europe-what-you-need-to-know\/","title":{"rendered":"Antibiotics shortages in Europe: what you need to know"},"content":{"rendered":"<p><span data-contrast=\"none\">\u201cA new approach is needed to better tackle medicines shortages in the European Health Union,\u201d the European Commission said in an official communication regarding current antibiotics shortages.<\/span><sup><span data-contrast=\"none\">1<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-contrast=\"none\">A 2018 analysis from the World Health Organisation estimates the cost of a shortage of just one antibiotic to be \u20ac20-30 million.<\/span><sup><span data-contrast=\"none\">2<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-contrast=\"none\">Discover the key facts around antibiotic shortages and what is being done to address them this season.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h2>Why have we been experiencing antibiotics shortages?<\/h2>\n<p><span data-contrast=\"none\">Unfortunately, antibiotics shortages have become more common.<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h3><span data-contrast=\"none\">One global analysis from 2018 found that antibiotics shortages could be attributed to:<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h3>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Lacking commercial incentive and market<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Weak forecasting systems<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Single-source or gaps in active pharmaceutical ingredients and other essential materials<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">Limited quality manufacturing of source materials<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"none\">Complex and fragmented procurement of products<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"none\">Regulatory challenges<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"none\">Inadequate constitutive recognition of access to essential medicines<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">A systematic review found that between 2019 and 2020, during the COVID-19 pandemic, antibiotic consumption rose in hospitals to treat bacterial coinfection.<\/span><sup><span data-contrast=\"none\">4<\/span><\/sup><span data-contrast=\"none\"> Some studies claimed interruptions or reductions in antibiotic stewardship programmes also played a role.<\/span><sup><span data-contrast=\"none\">4<\/span><\/sup><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"none\">The situation has continued to develop, with the winter of 2022-2023 bringing changing infection patterns resulting in an increased demand and in turn, a critical shortage of antibiotics.<\/span><sup><span data-contrast=\"none\">1<\/span><\/sup><span data-contrast=\"none\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Manufacturers found it challenging to respond quickly to the rising demand due to long lead times that would be needed to boost production.<\/span><sup><span data-contrast=\"none\">1<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h2>Who is impacted by antibiotics shortages?<\/h2>\n<p><span data-contrast=\"none\">Though the impact of shortages is not well documented in literature, we know that there is a direct impact on healthcare outcomes.<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-contrast=\"none\">Antibiotics shortages threaten effective, timely therapy.<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-contrast=\"none\">To ensure timely care, many healthcare professionals may resort to alternative antibiotics, which could impact the effectiveness of treatment.<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The use of suboptimal antibiotics could lead to drug-resistant infections and greater antimicrobial resistance.<\/span><sup><span data-contrast=\"none\">3<\/span><\/sup><span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"none\">In fact, the <a href=\"https:\/\/www.cdc.gov\/\">US Centre for Disease Control<\/a> estimates that unnecessary and suboptimal use of antibiotics could account for up to 50% of all outpatient antibiotic use, with 28% of prescriptions not needed at all.<\/span><sup><span data-contrast=\"none\">5<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">In the European Union, antimicrobial resistance is responsible for an estimated 33,000 deaths per year.<\/span><span data-contrast=\"none\">6<\/span><span data-contrast=\"none\"> Global deaths related to antimicrobial resistance are estimated to reach 10 million by 2050.<\/span><sup><span data-contrast=\"none\">7<\/span><\/sup><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-contrast=\"none\">It is also expensive; in 2019, antimicrobial resistance and its ineffective treatment cost European Economic Area healthcare systems \u20ac1.1 billion.<\/span><sup><span data-contrast=\"none\">6<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">More on this topic: <\/span><\/b><a href=\"https:\/\/eu.bd.com\/iv-news\/news-innovation\/achieving-infection-prevention-and-control\/\">Achieving infection prevention and control\u2014The Portuguese Experience<\/a><\/p>\n<h2>How can we ensure sufficient supply of antibiotics?<\/h2>\n<p><span data-contrast=\"none\">The European Medicines Agency (EMA)\u2019s Executive Steering Group on Shortages and Safety of Medicinal Products published three key ways that antibiotics shortages can be addressed in the region:<\/span><sup><span data-contrast=\"none\">8<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"none\">Increase production:<\/span><\/b><span data-contrast=\"none\"> Engage with marketing authorisation holders to prioritise measures that will increase production<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"none\">Monitor supply and demand:<\/span><\/b><span data-contrast=\"none\"> Order medicines as normal (no stockpiling) as the EMA, European Commission and Member States monitor supply and demand.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"none\">Awareness and responsible use:<\/span><\/b><span data-contrast=\"none\"> Only prescribe antibiotics to treat bacterial infections to help avoid antimicrobial resistance (not effective against viral infections, such as cold and flu)<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">The European Commission has proposed pharmaceutical legislation as well as measures to help improve the availability of key antibiotics, including an intensified information exchange with international companies and stakeholders to keep a close eye on the progress this winter season to detect and proactively address supply shortfalls.<\/span><sup><span data-contrast=\"none\">8<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Despite the calls to address shortages, the most recent data from the European Commission suggests that this season\u2019s supply of key antibiotics in the European Union should generally match demand, if demand doesn\u2019t significantly differ from previous years.<\/span><sup><span data-contrast=\"none\">8<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cA new approach is needed to better tackle medicines shortages in the European Health Union,\u201d the European Commission said in&#8230;<\/p>\n","protected":false},"author":8,"featured_media":6901,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-innovation","speciality-critical-care-emergency-care","speciality-infection-prevention","speciality-patient-safety","speciality-vascular-access","contenttype-article","target-doctor","target-hospital-director-manager","target-infection-prevention","target-nursing","target-patient","target-procurement"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Antibiotics shortages in Europe: what you need to know - BD IV News<\/title>\n<meta name=\"description\" content=\"European health agencies have been acting to 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